Hypercalcemia
Calcium levels controlled by the parathyroid (not related to thyroid function, just para - near it)
Overview here
Phys Asst info here
Overview here
Phys Asst info here
Hyperparathyroid as related to breast cancer
may lead to bone metastasis
see study link here - didn't finish reading
PTH-related peptide (PTHrP) is a secreted protein produced by breast cancer cells both in vivo and in vitro. Because of its structural similarity to PTH at the amino terminus, the two proteins interact with a common cell surface receptor, the PTH/PTHrP receptor. When overproduced by tumor cells, PTHrP enters the circulation, giving rise to the common paraneoplastic syndrome of humoral hypercalcemia of malignancy. ...These findings have critical implications regarding the role of PTHrP in breast cancer, and they suggest that controlling PTHrP production in breast cancer may be useful therapeutically.
see study link here - didn't finish reading
PTH-related peptide (PTHrP) is a secreted protein produced by breast cancer cells both in vivo and in vitro. Because of its structural similarity to PTH at the amino terminus, the two proteins interact with a common cell surface receptor, the PTH/PTHrP receptor. When overproduced by tumor cells, PTHrP enters the circulation, giving rise to the common paraneoplastic syndrome of humoral hypercalcemia of malignancy. ...These findings have critical implications regarding the role of PTHrP in breast cancer, and they suggest that controlling PTHrP production in breast cancer may be useful therapeutically.
Treatment
Vitamin D is currently the only Essential Vitamin or Mineral which appears to have deficiency rates at a similar level to Magnesium, if not greater. The metabolism of Vitamin D inherently is linked to Magnesium.
Magnesium levels in the brain can be negatively regulated by an excess of parathyroid hormone (PTH), where PTH causes release of calcium into the blood (being met with an increase of magnesium to retain homeostasis) possibly being a contributing factor to chronic depletion of magnesium concentration in neural tissue.[209] As vitamin D reliably suppresses excess PTH,[210][211] it may exert neural benefits secondary to preservation of Magnesium levels in the brain. |
what does "negatively regulated" mean? take Vit D to suppress PTH |
Also See
Paget's Disease of the Bone
Paget's disease of bone is medically unrelated to Paget's disease of the nipple, although it shares the same name.
While Paget's disease may affect any bone, the most commonly involved bones are the pelvis, vertebrae, skull, femur and tibia. Prevalent signs and symptoms of Paget's disease are skeletal deformity and bone pain. Pain usually results from the rheumatologic and neurologic complications of the disease rather than from the abnormal bone. When bone pain does occur among patients, its onset is frequently late in the disease process and is usually unrelated to physical activity. Pain from a pagetic lesion in the femur or tibia, however, may increase with weight bearing. A sudden onset of pain usually indicates that a fracture has occurred.
While Paget's disease may affect any bone, the most commonly involved bones are the pelvis, vertebrae, skull, femur and tibia. Prevalent signs and symptoms of Paget's disease are skeletal deformity and bone pain. Pain usually results from the rheumatologic and neurologic complications of the disease rather than from the abnormal bone. When bone pain does occur among patients, its onset is frequently late in the disease process and is usually unrelated to physical activity. Pain from a pagetic lesion in the femur or tibia, however, may increase with weight bearing. A sudden onset of pain usually indicates that a fracture has occurred.